The development of minimally-invasive real-time diagnostics that are easy to interpret and robust will provide monitoring of high-risk patients at point-of-care settings. In this talk, I will demonstrate photolithography and optical force nanomaterial assembly methods to create diffraction gratings in analyte-sensitive hydrogels that act as real-time biosensors. The applications of these biosensors are in continuous monitoring of metabolic biomarkers for point-of-care diagnostics and wearable devices. I will describe optical biosensing platforms including thin films, hydrogel optical fibers, lab-on-a-chip devices, paper-based microfluidics, contact lens microfluidics, and epidermal devices. I will also demonstrate medical smartphone applications for the quantification of colorimetric assays in telemedicine.
Ali K. Yetisen researches point-of-care diagnostics, biophotonics, wearable devices, and personalized medicine. He was previously a Tosteson postdoctoral fellow at Harvard University and Massachusetts General Hospital. Dr. Yetisen holds a Ph.D. degree in Chemical Engineering and Biotechnology from the University of Cambridge, and B.S. degree in Mechanical Engineering from the University of Arizona. He also lectures at Harvard-MIT Division of Health Sciences and Technology. Dr. Yetisen has been the driving force for the establishment of there spin-off companies, and has been awarded several national and international prizes including Carl Friedrich von Siemens Award, Humboldt Award, Wellman Discovery Award, Roche Continents Award, and the Ann & Norman Hilberry Award. He holds visiting scholar positions at the University of Birmingham and Technical University of Munich.