Angioplasty and stenting for atherosclerotic occlusive disease in the arteries supplying the legs (Peripheral Arterial Disease, PAD) is the most common endovascular procedure outside of the heart, but carries the highest rate of reconstruction failure. Though the underlying reasons for these poor results are not completely clear, the main arterial segment within the leg, the femoropopliteal artery, appears to be significantly different from other peripheral arteries, such as the carotid or iliac arteries, possibly because of lower blood flow, but more importantly because the femoropopliteal artery undergoes large deformations during flexion of the limb. These severe deformations are reflected clinically by the high incidence of stent fractures. The seminar will cover the biomechanics of the human femoropopliteal artery; describe new ways to measure limb flexion-induced arterial deformations; discuss mechanical properties and structure of the leg artery; and assess physiologic stresses and strains that play important roles in vascular remodeling and adaptation. We will also consider common PAD treatment devices and materials, discuss the role of patient-specific modeling in improving device and material design, and suggest potential ways to improve treatment outcomes.
Alexey Kamenskiy is an Assistant Professor in the Department of Surgery at the University of Nebraska Medical Center. He received his MS degree in Mechanics and Applied Mathematics from the Saratov State University, Russia and joined the graduate program of the Department of Engineering Mechanics at the University of Nebraska-Lincoln in 2005 where he studied hemodynamics and mechanics of human carotid arteries after open and endovascular repair. After completing his PhD and post-doctoral training, he joined the Department of Surgery of the University of Nebraska Medical Center in 2012. Current research interests of Dr. Kamenskiy include experimental and computational vascular mechanobiology, vascular pathophysiology and ageing, devices and materials for open and endovascular repair, and non-compressible hemorrhage control.