Our group studies the interaction of non-ionizing energy and biology at multiscale resolution, from cells through organ systems. Computer simulations are used to model biological response evoked upon exposure to energy and to design energy parameters that improve the specificity of the desired treatment effect. We develop novel medical devices for energy delivery in vitro and in vivo, allowing identification of signaling pathways and cellular activity that is altered or upregulated upon energy-based treatment. Our techniques allow the targeted modulation of barrier function in the tissue microenvironment (cell membrane, stroma and blood vessels), creating new platforms for the study of cancer and other diseases. The knowledge gained from our experiments has applications in tumor ablation, drug delivery, immunotherapy and tissue engineering. We emphasize rapid translation of our findings to the clinic through collaboration and involving physicians and other key stakeholders at all stages of our research.