The emerging field of biosensors based on two-dimensional (2D) materials with outstanding transduction properties offers a pathway to new opportunities in interrogation of biomarker biomolecules, highlighting next-generation point-of-care/implantable diagnostic tools. My talk will focus on biomolecular sensing with unprecedented high sensitivity and efficiency in power, size, and cost, using biosensing devices and systems enabled by 2D materials. I will discuss (1) the methodologies I developed to fabricate, functionalize, and implement small-scale 2D-based biosensing devices, (2) label-free detection of various biomarkers (nucleic acid oligomers, proteinaceous antigens, opioid-neuropeptides, pH) with high sensitivity, e.g. attomolar for DNA, by using the devices, and (3) a handheld multiplexed analytical robot enabled by 2D aptasensors to test real-world complex biosamples. I will also talk about preparation of large-size novel 2D materials via chemical vapor deposition and their characterization. I will conclude by presenting my ongoing work and vision for translation of multiplexed 2D-enabled system into portable/implantable diagnostic applications.
Dr. Jinglei Ping received B.S. from Sun Yat-sen University and Ph.D. from the University of Maryland–College Park. He was an occupational trainee in Monash University in 2013, followed by a postdoctoral stint at the University of Pennsylvania till 2015. Dr. Ping is currently a research associate in the University of Pennsylvania. His research focuses on translational biosensing devices/systems based on 2D materials. He has developed technologies for next-generation 2D-enabled point-of-care/implantable diagnostics applications: (1) scalable production of graphene-based biosensors with attomolar detection limit, (2) self-driven graphene microelectrode sensing arrays with negligible power consumption and heat dissipation, and (3) a 2D-enabled multiplexed sensing robot. Dr. Ping has authored over 17 scientific articles in high-impact peer-reviewed journals (Nature Communication, Chemical Science, Small, Nano Letters, ACS Nano, Physical Review Letters, et al.), 14 of which was published after 2014. Some of his work has been highlighted/reported by the journals and news media. Dr. Ping is also the inventor of three provisional patents and the recipient of the CEET (NIH) Pilot Award.