Application of electromagnetic energy to tissue can induce a variety of biophysical and biological changes. Computer simulations using multiphysics models can guide the selection and optimization of energy parameters for the induction of specific biological changes while avoiding undesirable effects such as tissue heating. Activation of cell signaling pathways, and changes in cell population and function also occur as a consequence of treatment with energy based therapies, which can be further augmented through combination with rationally chosen pharmacological agents. Electrode arrays can then be for controlled energy delivery in vivo. This talk will focus on application of these principles for the treatment of cancer through ablation and drug delivery in sensitive anatomical locations where surgery can cause severe, life-long morbidity to patients.
Dr. Srimathveeravalli joined UMass Amherst as an Asst. Professor in the Dept. of Mechanical and Industrial Engineering in Spring 2019, after serving as a faculty in the Dept. of Radiology at Memorial Sloan Kettering Cancer Center for six years. He is a member of the Institute for Applied Life Sciences where his lab studies the interaction of non-ionizing energy and biology at multiscale resolution ( sub-cellular – organ). Knowledge gained from experiments in his lab guide the development of medical devices and technology that will advance minimally invasive, image-guided therapy of cancer, and non-malignant diseases.
Dr. Srimathveeravalli got his PhD in mechanical engineering from the University at Buffalo, and received postdoctoral training on cancer research and image-guided therapy at Memorial Sloan Kettering Cancer Center. He has published 43 peer reviewed journal articles, has authored multiple textbook chapters on cancer ablation, and has been invited to speak at national and international symposia on cancer therapy. He is a member of the ISBETT, and serves on the organizing committee of the biennial congress.
His research has been supported by grants from the NIH, the Society of Interventional Radiology, Dept of Defense, industrial contracts, and various philanthropic foundations.