Abstract: Next-generation biomedicine and healthcare needs access of data at molecular and cellular levels. This can be achieved by molecule detection and cell imaging, two widely used approaches residing in today’s diagnostic and analytical medical devices. While great progress has been made in marketing these biomedical devices with improving performance, tools that can offer high precision cell interfacing and biosensing remain lacking. Building tools like this would open up opportunities in biomedicine and healthcare, such as cellular disease modeling and therapeutics development. Motivated by these, our research has been focused on accessing biology with high precision lab-on-a-chips, crossing disciplines in bioelectronics, optoelectronics, cell imaging, and nanodevices. In this talk, I will introduce our work on: 1) multifunctional cell interface to probe cell activities at high precision, specifically single-cell optogenetics and on-chip cell recording; 2) integrated biochips for label-free DNA detection, using CMOS and nano-sensor arrays.
Bio: Dr. Guangyu Xu received his B.S. and M.S. degrees from Tsinghua University. In 2011 he received his Ph.D. in Electrical Engineering from UCLA, where he studied the variability effects in graphene electronics. Afterwards, Dr. Xu received his postdoctoral training in the School of Engineering and Applied Sciences at Harvard University and the Synthetic Neurobiology Group at MIT Media Lab, where he developed label-free DNA arrays and multiplexed neuroimaging assays, respectively. Since 2016, he has been an Assistant Professor in the Department of Electrical and Computer Engineering at UMass Amherst. He currently works with a vivid group of students on developing multifunctional lab-on-chip technologies to provide new capabilities in biomedicine and healthcare.