Mechanical Engineering

Govind Srimathveeravalli

Assistant Professor

LSL N573

University of Massachusetts
160 Governors Drive
Amherst, MA 01003-2210

govind@umass.edu

Srimathveeravalli Research Group

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Education

PhD, SUNY, University at Buffalo
M.S., SUNY, University at Buffalo
B.E., University of Madras

Research

We develop technology for the delivery of non-ionizing energy that enables ablation or drug delivery to tumor and healthy living tissue. We use mathematical models to guide the design of novel medical devices to deliver energy to different locations in the body. We study the biological response of the tissue to energy delivery, and use that knowledge to improve treatment outcomes. Our work has applications in cancer therapy, nanoparticle and drug delivery, tissue engineering, and immunotherapy.

Program Area:

Mechanical Engineering

Research Area:

Biomedical & Healthcare Engineering

Publications

Kodama H, Ueshima E, Gao S, Monette S, Paluch LR, Howk K, Erinjeri JP, Solomon SB, Srimathveeravalli G. High Power Microwave Ablation of Normal Swine Lung: Impact of Duration of Energy Delivery on Adverse Event and Heat Sink Effects. Int J Hyperthermia. 2018 Feb 28:1-33.
Gu Y, Srimathveeravalli G, Cai L, Ueshima E, Maybody M, Yarmohammadi H, Zhu YS, Durack JC, Solomon SB, Coleman JA, Erinjeri JP. Pirfenidone inhibits cryoablation induced local macrophage infiltration along with its associated TGFb1 expression and serum cytokine level in a mouse model. Cryobiology. 2018 Apr 2.
Kodama H, Vroomen LGPH, Ueshima E, Reilly J, Brandt W, Paluch LR, Monette S, Jones D, Solomon SB, Srimathveeravalli G. Catheter Based Endobronchial Electroporation is Feasible for the Focal Treatment of Peri-Bronchial Tumors. J Thorac Cardiovasc Surg. 2017 Dec 2017.
Srimathveeravalli G, Abdel-Atti D, Perez-Medina C, Takaki H, Solomon SB, Mulder WJ and Reiner T. Imaging Reversible Electroporation Mediated Liposomal Doxorubicin Delivery in Tumors with Radiolabeled Nanoparticles. Mol Imaging. 2018 Jan-Dec; 2017.
Cornelis FH, Kim K, Durack JC, Jebiwott S, Scherz A, Srimathveeravalli G and Coleman JA. Contrast Enhanced Ultrasound Imaging can Predict Vascular Targeted Photodynamic Therapy Induced Tumor Necrosis in Small Animals. Photodiagnosis and Photodyn Ther. 2017 September.
Ueshima E, Schattner M, Mendelsohn R, Gerdes H, Monette S, Takaki H, Durack JC, Solomon SB and Srimathveeravalli G. Transmural Ablation of the Normal Porcine Common Bile Duct with Catheter-Directed Irreversible Electroporation is Feasible and Does Not Impact Duct Patency. J Gastrointenstinal Endoscopy. May 2017
Cornelis FH, Durack JC, Kimm SY, Wimmer T, Coleman JA, Solomon SB and Srimathveeravalli G. A Comparative Study of Ablation Boundary Sharpness After Pecutaneous Radiofrequency, Cryo-, Microwave, and Irreversible Electroporation Ablation in Normal Swine Liver and Kidneys. Cardiovasc Intervent Radiol. 2017 May;
Takaki H, Imai N, Thomas CT, Yamakado K, Hooman Y, Ziv E, Srimathveeravalli G, Sofocleous CT, Solomon SB, Erinjeri JP. Changes in peripheral blood T-cell balance after percutaneous tumor ablation. Minim Invasive Ther Allied Technol. 2017 Apr 18:1-7
Srimathveeravalli G, Cornelis F, Wimmer T, Monette S, Kimm SY, Maybody M, Solomon SB, Coleman JA, Durack JC. Normal Porcine Ureter Retains Lumen Wall Integrity but Not Patency Following Catheter-Directed Irreversible Electroporation: Imaging and Histologic Assessment over 28 Days. J Vasc Interv Radiol. 2017 Mar 30.
Boas FE, Srimathveeravalli G, Durack JC, Kaye EA, Erinjeri JP, Ziv E, Maybody M, Yarmohammadi H, Solomon SB. Development of a Searchable Database of Cryoablation Simulations for Use in Treatment Planning. Cardiovasc Intervent Radiol. 2017. Epub.
Kaye EA, Monette S, Srimathveeravalli G, Maybody M, Solomon SB, Gulati A. MRI-guided focused ultrasound ablation of lumbar medial branch nerve: Feasibility and safety study in a swine model. Int J Hyperthermia. 2016 Jul 21:1-9.
Murray KS, Ehdaie B, Musser J, Mashni J, Srimathveeravalli G, Durack JC, Solomon SB, Coleman JA. Pilot Study to Assess Safety and Clinical Outcomes of Irreversible Electroporation for Partial Gland Ablation in Men with Prostate Cancer. J Urol. 2016 Apr 23
Takaki H, Imai N, Contessa TT, Srimathveeravalli G, Covey AM, Getrajdman GI, Brown KT, Solomon SB, Erinjeri JP. Peripheral Blood Regulatory T-Cell and Type 1 Helper T-Cell Population Decrease after Hepatic Artery Embolization. J Vasc Interv Radiol. 2016 Apr 12.
14. Srimathveeravalli G, Cornelis F, Mashni J, Takaki H, Durack JC, Solomon SB, Coleman JA. Comparison of ablation defect on MR imaging with computer simulation estimated treatment zone following irreversible electroporation of patient prostate. Springerplus. 2016 Feb 29;5:219.
Kimm SY, Tarin TV, Monette S, Srimathveeravalli G, Gerber D, Durack JC, Solomon SB, Scardino PT, Scherz A, Coleman J. Nonthermal Ablation by Using Intravascular Oxygen Radical Generation with WST11: Dynamic Tissue Effects and Implications for Focal Therapy. Radiology. 2016 Mar 17:141571
Murray KS, Winter AG, Corradi RB, LaRosa S, Jebiwott S, Somma A, Takaki H, Srimathveeravalli G, Lepherd M, Monette S, Kim K, Scherz A, Coleman JA. Treatment Effects of WST11 Vascular Targeted Photodynamic Therapy for Urothelial Cell Carcinoma in Swine. J Urol. 2016 Jul;196(1):236-43.
Wimmer T, Srimathveeravalli G, Silk M, Monette S, Gutta N, Maybody M, Erinjeri JP, Coleman JA, Solomon SB, Sofocleous CT. Feasibility of a Modified Biopsy Needle for Irreversible Electroporation Ablation and Periprocedural Tissue Sampling. Technol Cancer Res Treat. 2015 Oct 6. [Epub ahead of print]
Kaye EA, Gutta NB, Monette S, Gulati A, Loh J, Srimathveeravalli G, Ezell PC, Erinjeri JP, Solomon SB, Maybody M. Feasibility Study on MR-Guided High-Intensity Focused Ultrasound Ablation of Sciatic Nerve in a Swine Model: Preliminary Results. Cardiovasc Intervent Radiol. 2015;38(4):985-92
Maybody M, Taslakian B, Durack JC, Kaye EA, Erinjeri JP, Srimathveeravalli G and Solomon SB. Feasibility of intermittent pneumatic compression for venous thromboembolism prophylaxis during magnetic resonance imaging-guided interventions. Eur J Radiol. 2015; 84(4):668-70.
Srimathveeravalli G, Silk M, Wimmer T, Monette S, Kimm S, Maybody M, Solomon SB, Coleman J and Durack JC. Feasibility of Catheter-Directed Intraluminal Irreversible Electroporation of Porcine Ureter and Acute Outcomes in Response to Increasing Energy Delivery. J Vasc Interv Radiol. 2015;26(7):1059-66
Lee KS, Takaki H, Yarmohammadi H, Srimathveeravalli G, Luchins K, Monette S, Nair S, Kishore S and Erinjeri JP. Pleural Puncture That Excludes the Ablation Zone Decreases the Risk of Pneumothorax after Percutaneous Microwave Ablation in Porcine Lung. J Vasc Interv Radiol. 2015;26(7):1052-8
Wimmer T, Srimathveeravalli G, Gutta NB, Ezell PC, Monette S, Maybody M, Durack JC, Erinjeri JP and Solomon SB. Planning Irreversible Electroporation (IRE) in the Porcine Kidney: Are Numerical Simulations Reliable for Predicting Empiric Ablation Outcomes? Cardiovasc Intervent Radiol. 2015;38(1):182-90.
Cornelis F, Takaki H, Laskhmanan M, Durack JC, Erinjeri JP, Getrajdman GI, Maybody M, Sofocleous CT, Solomon SB and Srimathveeravalli G. Comparison of CT Fluoroscopy-Guided Manual and CT-Guided Robotic Positioning System for In Vivo Needle Placements in Swine Liver. Cardiovasc Intervent Radiol. Cardiovasc Intervent Radiol. 2015;38(5):1252-60
Srimathveeravalli G, Kim C, Petrisor D, Ezell P, Coleman J, Solomon S, Stoianovici D, and Hricak H. MRI-Safe Robot for Targeted Transrectal Prostate Biopsy: Animal Experiments. BJU Int. 2014;113(6):977-85.
Tam AL, Abdelsalam ME, Gagea M, Ensor JE, Moussa M, Ahmed M, Goldberg SN, Dixon K, McWatters A, Miller JJ, Srimathveeravalli G, Solomon SB, Avritscher R, Wallace MJ, Gupta S. Irreversible Electroporation of the Lumbar Vertebrae in a Porcine Model: Is There Clinical-Pathologic Evidence of Neural Toxicity? Radiology. 2014;272(3):709-19.
Silk M, Wimmer T, Lee KS, Srimathveeravalli G, Brown KT, Sofocleous CT, Kingham PT, Fong Y, Durack JC and Solomon SB. Percutaneous Ablation of Peri-Biliary Tumors with Irreversible Electroporation (IRE). J Vasc Interv Radiol. 2014;25(1):112-8.
Krishnaswamy S, Shriber L and Srimathveeravalli G. The Design And Efficacy of A Robot Mediated Visual Motor Program for Children Learning Disabilities. J of Comp Asst Learning. 2014; 30(2):121-131.
Stoianovici D, Kim C, Srimathveeravalli G, Sebrecht P, Petrisor D, Coleman J, Solomon SB and Hricak H. MRI-Safe Robot for Endorectal Prostate Biopsy. IEEE ASME Trans Mechatron. 2013;19(4):1289-1299.
Srimathveeravalli G, Wimmer T, Monette S, Ezell PC, Gutta NB, Maybody M, Weiser MR and Solomon SB Evaluation of an Endorectal Electrode for Performing Focused Irreversible Electroporation Ablations in the Swine Rectum. J Vasc Interv Radiol. 2013;24(8):1249-56.
Wimmer T, Srimathveeravalli G, Gutta NB, Ezell PC, Monette S, Kingham PT, Durack JC, Fong Y and Solomon SB. Comparison of Simulation Based Treatment Planning to Imaging and Pathology Outcomes for Percutaneous CT-Guided Irreversible Electroporation of the Porcine Pancreas: A Pilot Study. J Vasc Interv Radiol. 2013;24(8):1249-56.
Srimathveeravalli G, Leger J, Ezell P, Maybody M, Gutta N, Solomon SB. A study of porcine liver motion during respiration for improving targeting in image-guided needle placements. Int J Comput Assist Radiol Surg. 2013;8(1):15-27.
Subrahmaniyan N, Krishnaswamy S, Chowriappa A, Srimathveeravalli G, Bisantz A, Shriber L and Kesavadas T. A Visual Haptic System for Children with Learning Disabilities: Software and Hardware Design Considerations. J of Interactive Learning Res. 2013; 23(2): 113-141
Seixas-Mikelus SA, Stegemann AP, Kesavadas T, Srimathveeravalli G, Sathyaseelan G, Chandrasekhar R, Wilding GE, Peabody JO, Guru KA. Content validation of a novel robotic surgical simulator. BJU Int. 2011;107(7):1130-5.
Kesavadas T, Stegemann A, Sathyaseelan G, Chowriappa A, Srimathveeravalli G, Seixas-Mikelus S, Chandrasekhar R, Wilding G, Guru K. Validation of Robotic Surgery Simulator (RoSS).Stud Health Technol Inform. 2011;163:274-6.
Seixas-Mikelus SA, Kesavadas T, Srimathveeravalli G, Chandrasekhar R, Wilding GE, Guru KA. Face validation of a novel robotic surgical simulator. Urology. 2010;76(2):357-60.
Srimathveeravalli G, Kesavadas T, Li X. Design and fabrication of a robotic mechanism for remote steering and positioning of interventional devices. Int J Med Robot. 2010;6(2):160-70.
Seixas-Mikelus SA, Adal A, Kesavadas T, Baheti A, Srimathveeravalli G, Hussain A, Chandrasekhar R, Wilding GE, Guru KA. Can image-based virtual reality help teach anatomy? J Endourol. 2010; 24(4):629-34.
Srimathveeravalli G, Gourishankar V, Kumar A and Kesavadas T. Experimental Evaluation of Shared Control for Rehabilitation of Fine Motor Skills, ASME J. Comput. Inf. Sci. Eng. 2009; 9(1):82-90.
39. Arulesan V, Srimathveeravalli G, Kesavadas T, Nagathan P, Baier RE. Data acquisition and development of a trocar insertion simulator using synthetic tissue models. Stud Health Technol Inform. 2007;125:25-7.
Kesavadas T, Srimathveeravalli G, Arulesan V. Parametric modeling and simulation of trocar insertion. Stud Health Technol Inform. 2006;119:252-4.

Honors

Abstract of the Year, Society of Interventional Radiology Annual Meeting, 2018
Travel Award for Collaboration, Govt. of Slovenia, 2017
Research Mentor of the Year, Dept. of Radiology, MSKCC, 2017
Best Reviewer, Eng. in Urology Symposium, AUA, 2014
Top 10 Abstract, Eng. in Urology Symposium, AUA, 2014
Featured Talk, Society of Interventional Radiology Annual Meeting, 2014
Cum Laude for Poster, CIRSE Annual Meeting, 2013
Top 10 Abstract, Eng. in Urology Symposium, AUA, 2013
Best Poster Award, Society of Interventional Radiology Annual Meeting, 2013
Featured Talk, Society of Interventional Radiology Annual Meeting, 2013
Outstanding Paper Award, Eng. in Urology Symposium, AUA, 2012
Professional Development Award, University at Buffalo, 2007
Graduate Student Research Award, University at Buffalo, 2005 & 2006
Conference Travel Award, Graduate Student Association, University at Buffalo, 2018
Graduate Education Scholarship, Sir Ratan Tata Trust, India, 2002
7th Rank in University, First Class with Distinction, University of Madras, 2002

Links

Lab Affiliation:

Srimathveeravalli Research Group

Yanfei Xu

Assistant Professor

LGRT 403E

yanfeixu@umass.edu

Google Scholar

APEX Research Group

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Education

2005-2010 Ph.D. Organic Chemistry, Nankai University
2011-2013 Marie Curie Fellow of European Commission, Max Planck Institute for Polymer Research & BASF SE Joint Lab
2013-2018 Postdoctoral Associate, Mechanical Engineering, Massachusetts Institute of Technology

Research

Our interdisciplinary research focuses on exploring fundamental relationships between material structures and properties at an atomic level; engineering polymers and carbon-based nanomaterials to improve thermal, electrical and optical properties; translating materials into integrated devices and systems by leveraging advanced manufacturing; and enhancing functionality during manufacturing. Potential applications include electronics, optics, optoelectronics, and thermal energy storage and conversion.

Program Area:

Mechanical Engineering

Research Area:

Advanced Design & Manufacturing

Publications

Y. Xu, D. Kraemer, B. Song, Z. Jiang, J. Zhou, J. Loomis, J. Wang, M. Li, H. Ghasemi, X. Huang, X. Li, G Chen*. Bulk Polymer with metal-like thermal conductivity. https://arxiv.org/abs/1708.06416
Y. Xu, et al. Molecular engineered conjugated polymer with high thermal conductivity. Science Advances, 2018, 4, eaar3031.
Y. Xu, I. Hennig, D. Freyberg, A. Strudwick, M. Schwab, T. Weitz, and K. Cha. Inkjet-printed Energy Storage Device Using Graphene/polyaniline Inks. Journal of Power Sources, 2014, 248, 483-488.
Y. Xu, M. Schwab, A. Strudwick, I. Hennig, X. Feng, Z. Wu, and K. Müllen*. Screen-Printable Thin Film Supercapacitor Device Utilizing Graphene/Polyaniline Inks. Advanced Energy Materials, 2013, 3, 1035-1040.
Y. Xu, Y. Huang, W. Yan, L. Zhang, Y. Chen. Environmentally Friendly Approaches Toward the Production of Processable Graphene by Exfoliation of Graphite Using Ionic Liquid, Journal of nanoscience and nanotechnology, 2013, 13, 1116-1119.
Y. Xu, G. Long, L. Huang, Y. Huang, X. Wan, Y. Ma, and Y. Chen*. Polymer Photovoltaic Devices with Transparent Graphene Electrodes Produced by Spin-casting. Carbon, 2010, 48, 3308-3311.
Y. Xu, Z. Liu, X. Zhang, Y. Wang, J. Tian*, Y. Huang, Y. Ma, X. Zhang, and Y. Chen*. A Graphene Hybrid Material Covalently Functionalized with Porphyrin: Synthesis and Optical Limiting Property. Advanced Materials, 2009, 21, 1275-1279 (855+ citations).
Y. Xu, Y. Wang, J. Liang, Y. Huang, Y. Ma, X. Wan, and Y. Chen*. A Hybrid Material of Graphene and Poly (3,4-ethyldioxythiophene) with High Conductivity, Flexibility, and Transparency. Nano Research, 2009, 2, 343-348.
W. Yan, Y. Xu, L. Huang, Y. Chen*. Controllable and Reversible Dispersiblity of Graphene Materials by a Generic Organometallic Functionalization, Journal of Nanoscience and Nanotechnology, 2015, 15, 2032-2039.
W. Yan, Y. Xu, Y. Chen*. Facile and Effective Functionalization of Graphene Oxide by Boron–Oxygen Covalent or Bingel Cyclopropanation Reaction, Journal of Nanoscience and Nanotechnology, Journal of Nanoscience and Nanotechnology 2015, 15, 2020-2026.
Y. Chen*, Y. Xu, K. Zhao, X. Wan, J. Deng, and W. Yan. Towards Flexible All-Carbon Electronics: Flexible Organic Field-Effect Transistors and Inverter Circuits Using Solution-
Processed All Graphene Source/Drain/Gate Electrodes. Nano Research, 2010, 3, 714-721 (Cover Story).
J. Liang, Y. Xu, D. Sui, L. Zhang, Y. Huang, Y. Ma, F. Li, and Y. Chen*. Flexible, Magnetic, and Electrically Conductive Graphene/Fe3O4 Paper and Its Application for Magnetic-Controlled Switches. The Journal of Physical Chemistry C, 2010, 114, 17465-17471.
Z. Liu, Y. Xu, X. Zhang, X. Zhang, Y. Chen*, and J. Tian*. Porphyrin and Fullerene Covalently Functionalized Graphene Hybrid Materials with Large Nonlinear Optical Properties. The Journal of Physical Chemistry B, 2009, 113, 9681-9686.
J. Liang, Y. Xu, Y. Huang*, L. Zhang, Y. Wang, Y. Ma, F. Li, T. Guo, and Y. Chen*. Infrared-triggered Aactuators from Graphene-based Nanocomposites. The Journal of Physical Chemistry C, 2009, 113, 9921-9927.
Y. Huang, W. Yan, Y. Xu L. Huang, Y. Chen*, Functionalization of Graphene Oxide by Two-Step Alkylation. Macromolecular Chemistry and Physics, 2012, 213, 1101-1106.
W. Yan, Y. Huang, Y. Xu, L Huang, Y. Chen*, Rapid and Effective Functionalization of Graphene Oxide by Ionic Liquid. Journal of nanoscience and nanotechnology 2012, 12, 2270-2277.
Z. Liu, L. Li, Y. Xu, J. Liang, X. Zhao, S. Chen, Y. Chen, J. Tian*, Direct Patterning on Reduced Graphene Oxide Nanosheets using Femtosecond Laser Pulses. Journal of Optics, 2011, 13, 085601.
J. Liang, Y. Chen*, Y. Xu, Z. Liu, L. Zhang, X. Zhao, X. Zhang, J. Tian, Y. Huang, Y. Ma, F. Li. Toward all-carbon electronics: fabrication of graphene-based flexible electronic circuits and memory cards using maskless laser direct writing. ACS applied materials & interfaces, 2010, 2, 3310-3317.
W. Yan, X. Wan, Y. Xu, X. Lv, Y. Chen*, A Phenalenyl-based Neutral Stable π-conjugated Polyradical, Synthetic Metals 2009, 159, 1772-1777.
Z. Liu, Y. Wang, X. Zhang, Y. Xu, Y. Chen, J. Tian*, Nonlinear Optical Properties of Graphene Oxide in Nanosecond and Picosecond Regimes. Applied Physics Letters 2009, 94, 021902.
J. Tong, X. Huang, S. Boriskina, J. Loomis, Y. Xu, G. Chen*, Infrared-Transparent Visible-Opaque Fabrics for Wearable Personal Thermal Management. ACS Photonics, 2015, 2, 769-778.
Hybrid Optical-Thermal Devices and Materials for Light Manipulation and Radiative Cooling. S. Boriskina, J. Tong, W. Hsu, L. Weinstein, X. Huang, J. Loomis, Y. Xu, G. Chen*. SPIE Nanoscience + Engineering, 2015, 95461U-95461U-7.
J. Loomis, H. Ghasemi, X. Huang, J. Wang, N. Thoppey, J. Tong, Y. Xu, X. Li, C. Lin, and G. Chen. Continuous Fabrication Platform for Highly Aligned Polymer Films, Technology, 2014, 2,189-199.
X. Zhang, X. Zhao, Z. Liu, S. Shi, W. Zhou, J. Tian*, Y. Xu, Y. Chen. Nonlinear Optical and Optical Limiting Properties of Graphene Oxide-Fe3O4 Hybrid Material. Journal of Optics, 2011, 13, 075202.
Y. Li, Y. Li, W. Shi, S. Chen, G. Zhang, Z. Liu, Q. Sun, J. Tian*, Y. Xu, Y. Chen. Periodic Microstructures Fabricated by Multiplex Interfering Femtosecond Laser Beams on Graphene Sheet. International Journal of Nanomanufacturing, 2012, 8, 221-230.
X. Zhang, Z. Liu, X. Li, Q. Ma, X. Chen, J. Tian*, Y. Xu, Y. Chen. Transient Thermal Effect, Nonlinear Refraction and Nonlinear Absorption Properties of Graphene Oxide Sheets in Dispersion. Optics express, 2013, 21, 7511-7520.
G. Ni, N. Miljkovic, H. Ghasemi, X. Huang, S. Boriskina, C. Lin, J. Wang, Y. Xu, M. Rahman, T. Zhang, G Chen*, Volumetric Solar Heating of Nanofluids for Direct Vapor Generation, 2015, 17, 290-301.

BOOK CHAPTERS

Y. Huang, W. Yan, Y. Xu, L Huang, and Y. Chen, Chemical Synthesis and Applications of Graphene and Carbon Materials, Print ISBN: 9783527332083, Wiley, 2016.

Patents

G. Chen, H. Ghasemi, J. Loomis, J. Wang, X. Huang, and Y. Xu. Continuous fabrication platform for highly aligned polymer films, MIT Case NO. 17065K, US Utility Patent Filed.
G. Chen, Y. Xu, J. Wang, J. Zhou. Electrically insulating and thermally conductive polymer-polymer composite material, MIT Case18510 and provisional patent.
G. Chen, J. Tong, S. Boriskina, X. Huang, J. Loomis, Y. Xu. Infrared transparent visible opaque fabrics (ITVOF), US Patent MIT Case NO. 17,390.
G. Chen, Y. Xu, X. Wang, K. Gleason, Molecular engineered conjugated polymer with high thermal conductivity, MIT Case NO. 20030.
Y. Xu, M. Schwab, and I. Hennig. Graphene based screen-printable ink and its use in supercapacitors, WO2014072877A3.
X. Wan, Y. Xu, Y. Chen, Y. Ma, and Y. Huang. Single layer oxidation graphite composite hybridization material and method for preparing same and applications, CN101387810B.
Y. Chen, Y. Ma, Y. Huang, J. Liang, L. Zhang, Y. Wang, Y. Xu, and F. Li. Photo-induced shape memory composite and production thereof, WO2010045890 A1.
Y. Chen, Y. Huang, Y. Ma, J. Liang, Y. Wang, X. Zhang, and Y. Xu. Polymer composite and its preparation method, WO2010045887 A1.
X. Wan, Y. Xu, Y. Chen, Y. Ma, and Y. Huang. Sulfonated mono-layer graphite and polymer compound material and preparation and application thereof, CN101381507 A.
X. Zhang, J. Liang, Y. Wang, Y. Xu, Y. Chen, Y. Ma, and Y. Huang. Mono-layer graphite and polymer compound material and preparation and application thereof, CN 200810152466.

Honors

2016 Top 10 Reviewers, JMCC, Royal Society of Chemistry
2015 Featured Speaker, TechConnect World Innovation Conference
2011-2012 Marie Curie Fellowship, European Commission
2011 Best Doctoral Dissertation Award, Nankai University
2009 Top 100 Most Influential Scientific Researchers, P. R. China (中国百篇最具影响国际学术论文)

Jinglei Ping

Assistant Professor

S507 Life Science Laboratories
University of Massachusetts
160 Governors Drive
Amherst, MA 01003-2210

ping@engin.umass.edu

(413) 545-3395

Nano/Bio Interface Lab

Horizontal Tabs

Education

B.S. (with highest honor), Sun Yat-sen University, 2003
M. Phil., Sun Yat-sen University, 2008
Ph.D., University of Maryland–College Park, 2013

Research

Development of biosensing devices and systems based on two-dimensional (2D) materials and translation of 2D materials into applications in point-of-care diagnostics, drug testing, and healthcare.

Program Area:

Mechanical Engineering

Research Area:

Links

Lab Affiliation:

Nano/Bio Interface Lab

Xian Du

Assistant Professor

S421 Life Science Laboratories

University of Massachusetts
240 Thatcher Way
Amherst, MA 01003

xiandu@umass.edu

(413) 577 - 0941

(413) 545 - 1027

Intelligent Sensing Lab

Horizontal Tabs

Education

Ph.D. Innovation in Manufacturing Systems and Technology, Singapore-MIT Alliance, National University of Singapore; Singapore and Cambridge, MA
M.S. Mechatronics Engineering, Shanghai Jiaotong University; Shanghai, China
B.S. Mechanical Engineering, Tianjin University; Tianjin, China

Research

Xian Du's research focuses on the scale up of flexible electronics printing processes from lab to industry using high-precision in-line inspection and pattern recognition technologies for large surface quality control. He also works on automatic, high resolution, accurate, and robust imaging tools for medical devices for noninvasive detection and description of biomarkers.

Program Area:

Mechanical Engineering

Research Area:

Biomedical & Healthcare Engineering

Publications

Please see my Google Scholar page

Links

CV:

Du Xian CV.pdf

Lab Affiliation:

Intelligent Sensing Lab

Tingyi “Leo” Liu

Assistant Professor

S417 Life Science Laboratories

160 Governors Drive
Amherst, MA 01003

leoliu@umass.edu

Phone: (413) 577 - 0927

Fax: (413) 545 - 1027

Interdisciplinary Interface Engineering Laboratory

Horizontal Tabs

Education

Ph.D., University of California, Los Angeles (UCLA), Mechanical Engineering, 2014

M.S., University of California, Los Angeles (UCLA), Mechanical Engineering, 2011

B.E., Zhejiang University, Electrical Engineering, 2009

Research

Interdisciplinary interface engineering, such as：

• Bio-inspired soft robotics; Soft electronics; Medical devices;

• Advanced manufacturing; Heterogeneous integration; Roll-to-roll (R2R) manufacturing;

• Super-repellent surfaces; Superomniphobic surfaces; Superhydrophobic surfaces;

• Liquid-metal-based micro/nano-devices;

• Fundamentals of interfacial phenomena;

• Anti-biofouling surfaces;

• Personalized medicine; Complex systems.

Program Area:

Mechanical Engineering

Research Area:

Publications

Journals

T. Liu, and C.-J. Kim, “Contact angle measurement of small capillary length liquid in super-repelled state,” Scientific Reports, vol. 7, no. 1, p. 740, Apr. 2017.
T. Liu, Z. Chen, and C.-J. Kim, “A dynamic Cassie-Baxter model, ” Soft Matter, Vol. 11, Iss. 8, Feb. 2015, pp. 1589–1596.
T. Liu and C.-J. Kim, “Turning a surface superrepellent even to completely wetting liquids,” Science, Vol. 346, Iss. 6213, Nov. 2014, pp. 1096-1100.
G. Sun, T. Liu, P. Sen, W. Shen, C. Gudeman and C.-J. Kim, “Electrostatic Side-Drive Rotary Stage on Liquid-Ring Bearing,” Journal of Microelectromechanical Systems. Vol. 23, Iss.1, Feb. 2014, pp. 147-156.
T. Liu, P. Sen, and C.-J. Kim, “Characterization of Nontoxic Liquid-Metal Alloy Galinstan® for Applications in Micro Devices,” Journal of Microelectromechanical Systems, Vol. 21, Iss. 2, April 2012, pp. 443-450.

Conference Proceedings (Refereed)

T. Man, X. Zhu, Y. T. Chow, T. Liu, X. Wen, M. A. Teitell, P.-Y. Chiou, “Photothermal Intracellular Delivery with Self-Aligned Cell Seeding,” Proc. IEEE Int. Conf. on Optical MEMS and Nanophotonics (OMN), Santa Fe, New Mexico, USA, Aug. 2017.
T. Liu, X. Wen, Y.-C. Kung, and P. Y. Chiou, “Fabrication Strategy For Micro Soft Robotics With Semiconductor Devices Integration,” Proc. IEEE Int. Conf. MEMS, Las Vegas, USA, Jan. 2017, pp. 663-666.
X. Wen, T. Liu, and P.-Y. Chiou, “A Hybrid Silicon-PDMS Multifunctional Neural Probe,” Proc. IEEE Int. Conf. on Optical MEMS and Nanophotonics (OMN), Singapore, Jul. 2016.
T. Liu and C.-J. Kim, “Structure-Based Superhydrophobicity for Serum Droplets,” Proc. IEEE Int. Conf. MEMS, Estoril, Portugal, Jan. 2015, pp. 6-7.
T. Liu and C.-J. Kim, “Doubly Re-entrant Cavities to Sustain Boiling Nucleation In FC-72,” Proc. IEEE Int. Conf. MEMS, Estoril, Portugal, Jan. 2015, pp. 1122-1124.
T. Liu and C.-J. Kim, “Microstructured SiO2 Surface Repellant to Liquids without Coating,” Proc. Int. Conf. Solid State Sensors, Actuators and Microsystems (Transducers’13), Barcelona, Spain, June 2013, pp. 1609-1612.
T. Liu, G. Sun, J. J. Kim, C.-K. K. Yang, and C.-J. Kim, “Electrostatic Bottom-Driven Rotary Stage on Multiple Conductive Liquid-Ring Bearings,” Proc. IEEE Int. Conf. MEMS, Taipei, Taiwan, Jan. 2013, pp. 86-89.
G. Sun, T. Liu, P. Sen, W. Shen, C. Gudeman, and C.-J. Kim, “Electrostatically Driven Rotor on Conductive Liquid Ring Bearings,” Technical Digest, Solid-State Sensor, Actuator and Microsystems Workshop, Hilton Head Island, SC, June 2012, pp. 78-81.
T. Liu, P. Sen, and C.-J. Kim, “Characterization of Liquid-Metal Galinstan® for Droplet Applications”, Proc. IEEE Int. Conf. MEMS, Hong Kong, China, Jan. 2010, pp. 560-563.

Links

Lab Affiliation:

Interdisciplinary Interface Engineering Laboratory

Wen Chen

Assistant Professor

Starting in May 2018

wenchen@umass.edu

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Education

2015: Ph.D. Mechanical Engineering & Materials Science, Yale University
2011: M.Phil. Industrial and Systems Engineering, The Hong Kong Polytechnic University
2008: B.Eng. Materials Science and Engineering, Nanjing University of Science and Technology

Research

Materials Science and also Advanced Design & Manufacturing

Program Area:

Mechanical Engineering

Research Area:

Materials Science

Publications

Y. M. Wang, T. Voisin, J.T. McKeown, J.C. Ye, N.P. Calta, Z. Li, Z. Zeng, Y. Zhang, W. Chen, T.T. Roehling, R.T. Ott, M.K. Santala, P.J. Depond, M.J. Matthews, A.V. Hamza, T. Zhu, Additively-manufactured hierarchical stainless steels with high strength and ductility, Nature Materials, in press, 2017.
F. Qian, P.C. Lan, M.C. Freyman, W. Chen, T. Kou, T.Y. Olson, C. Zhu, M.A. Worsley, E.B. Duoss, C.M. Spadaccini, T. Baumann, T.Y. Han, Nano Letters. 2017, DOI: 10.1021/acs.nanolett.7b02790.
C. Zhu, T. Kou, F. Qian, W. Chen, S. Chandrasekaran, B. Yao, Y. Song, J.D. Kuntz, E.B. Duoss, C.M. Spadaccini, M.A. Worsley, Y. Li, 3D Printed Functional Nanomaterials for Electrochemical Energy Applications: a Review, Nano Today, 15, 2017. (Invited Review)
W. Chen, L. Thornley, H.G. Coe, C. Zhu, E.B. Duoss, R.M. Hunt, M.J. Wight, D. Apelian, A.J. Pascall, J.D. Kuntz, C.M. Spadaccini, Direct metal writing: Controlling the rheology through microstructure, Applied Physics Letters, 110 (2017) 094104.
W. Chen, H.F. Zhou, Z. Liu, J. Ketkaew, N. Li, J. Yurko, N. Hutchinson, H.J. Gao, J. Schroers, Processing effects on fracture toughness of metallic glasses, Scripta Materialia, 130 (2017) 152-156.
W. Chen, Z. Liu, J. Ketkaew, R. Mota, S. Kim, M. Power, W. Samela, J. Schroers, Flaw tolerance of metallic glasses, Acta Materialia, 107 (2016) 220-228.
N. Li, W. Chen, L. Liu, Thermoplastic micro-forming of bulk metallic glasses: A Review, JOM, 68 (2016) 1246-1261. (Invited Review)
D.J. Magagnosc, W. Chen, G. Kumar, J. Schroers, D.S. Gianola, Thermomechanical behavior of molded metallic glass nanowires, Scientific Reports, 6 (2016) 19530.
C. Su, Y. Chen, P. Yu, M. Song, W. Chen, S.F. Guo, Linking the thermal characteristics and mechanical properties of Fe-based bulk metallic glasses, Journal of Alloys and Compounds, 663 (2016) 867-871.
Z. Liu*, W. Chen*, J. Carstense, J. Ketkaew, R. Mota, J.K. Guest, J. Schroers, 3D metallic glass cellular structures, Acta Materialia, 105 (2016) 35-43.

Honors

Acta Student Award, The Acta Journals, 2016
Second Place Poster Award, 11th International Bulk Metallic Glasses Conference, 2016
Chinese Government Award for Outstanding Oversea Students, 2016
Pierre W. Hoge Fellowship, Yale University, 2011 - 2015
Yale Graduate Conference Travel Grant Award, 2015
"ScienceDirect Top 25 Hottest Articles", Scripta Materialia, 107 (2015): 1-4 , 2015
"Outstanding Reviewer" awarded by Materials Science and Engineering: A, 2015
"Outstanding Reviewer" awarded by Materials Science and Engineering: B, 2014
"ScienceDirect Top25 Hottest Articles", Acta Materialia, 62 (2014): 49-57 , 2013
Hong Kong Government M.Phil. Fellowship, 2009-2011
First-class Scholarship, Nanjing University of Science and Technology, 2006-2008

Links

CV:

cv_wen_chen.pdf

Lab Affiliation:

Multi-scale Materials and Manufacturing Laboratory

Yubing Sun

Assistant Professor

N571 Life Science Laboratories

University of Massachusetts
160 Governors Drive
Amherst, MA 01003-2210

ybsun@umass.edu

(413) 545-4543

(413) 545-1027

Laboratory for Multiscale Bioengineering and Mechanobiology

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Education

B.S., University of Science and Technology of China, 2010
Ph.D., University of Michigan, Ann Arbor, 2015

Research

Our research applies and integrates fundamental engineering principles, such as manufacturing, biomechanics, materials science, and micro/nanoengineering, to understand and harness the mechanobiology of stem cells for modeling currently incurable human diseases and for applications in regenerative medicine. Current research interests include:

Stem cell bioengineering
System mechanobiology
Microengineering
Active biomaterials
Lab-on-chip
Tissue biomechanics

Program Area:

Mechanical Engineering

Research Area:

Publications

Weiqiang Chen, Shuo Han, Weiyi Qian, Shinuo Weng, Haiou Yang, Yubing Sun, Luis G. Villa-Diaz, Paul H. Krebsbach, and Jianping Fu. Nanotopography Regulates Motor Neuron Differentiation of Human Pluripotent Stem Cells. Nanoscale, in press, 2018.
Bin Zhao, Casey O’Brien, Aruni P. K. K. Karunanayake Mudiyanselage, Ningwei Li, Yousef Bagheri, Rigumula Wu, Yubing Sun, and Mingxu You. Visualizing Intercellular Tensile Forces by DNA-Based Membrane Molecular Probes. Journal of the American Chemical Society, vol. 139, 18182. 2017.
Nariman Banaei, Anne Foley, JeanMarie Houghton, Yubing Sun#, and Byung Kim#. Multiplex detection of pancreatic cancer biomarkers using a SERS-based immunoassay. Nanotechnology, vol. 28, 45, 2017.
1. Selected as the Annual Highlights of 2017 by Nanotechnology
Xin Cui, Weijin Guo, Yubing Sun, Baoce Sun, Shuhuan Hu, Dong Sun, Raymond HW Lam. A microfluidic device for isolation and characterization of transendothelial migrating cancer cells. Biomicrofluidics, vol. 11, 014105, 2017.
Tianfa Xie, Jamar Hawkins, Yubing Sun#. Traction Force Measurement Using Deformable Microposts. In: Rittié L. (eds) Fibrosis. Methods in Molecular Biology, vol. 1627, Humana Press, New York, NY, 2017.
Koh Meng Aw Yong, Yubing Sun, Sofia D. Merajver, and Jianping Fu. Mechanotransduction-induced reversible phenotypic switching in prostate cancer cells. Biophysical Journal, vol.112, pp. 1236-1245, 2017.

Honors

ProQuest Distinguished Dissertation Awards, Honorable Mention, UMich, 2015
Chinese Government Award for Outstanding Self-Financed Students Abroad, CSC, 2014
Robert M. Caddell Memorial Award for Research, UMich, 2014
Rackham Conference Travel Grant, UMich, 2012, 2013, 2014
Rackham International Students Fellowship, UMich, 2011
Department Fellowship, Department of Mechanical Engineering, UMich, 2010
Lixun Scholarship, Institute of Metal Research, Chinese Academy of Sciences, 2009
Ya Yang Scholarship, USTC Alumni Foundation, 2008
Outstanding Student Scholarship (Grade1), USTC, 2007, 2008
National Lizhi Scholarship, Ministry of Education of the P. R. China, 2007
813 Award, USTC Alumni Foundation, 2007

Links

CV:

YubingSun-CV.pdf

Juan Jiménez

Assistant Professor

N575 Life Sciences Laboratory

240 Thatcher Way
University of Massachusetts
Amherst, MA 01003-2210

email: juanjimenez at umass.edu

Jiménez Research Group

UMass IALS

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Education

BS, Michigan State University, 1999
MS, Princeton University, 2002
PhD, Princeton University, 2007
Postdoctoral Fellowship, University of Pennsylvania, 2011

Research

Biomedical Engineering
Biofluids
Fluid Dynamics
Cardiovascular Engineering
Medical Devices
Vascular Biology
Cell Motility & Dynamics

Program Area:

Mechanical Engineering

Research Area:

Publications

Davies PF, Manduchi E, Jiménez JM, Jiang YZ 2017. Biofluids, cell mechanics and epigenetics: Flow-induced epigenetic mechanisms of endothelial gene expression. Journal of Biomechanics 50, 3-10
Sweet DT, Jiménez JM, Chang J, Hess PR, Mericko-Ishizuka P, et al. 2015. Lymph flow regulates collecting lymphatic vessel maturation in vivo. J Clin Invest
Jiang YZ, Manduchi E, Jiménez JM, Davies PF. 2015. Endothelial epigenetics in biomechanical stress: Disturbed flow-mediated epigenomic plasticity in vivo and in vitro. Arteriosclerosis, Thrombosis, and Vascular Biology
Jiménez JM, Prasad V, Yu MD, Kampmeyer CP, Kaakour AH, et al. 2014. Macro- and microscale variables regulate stent haemodynamics, fibrin deposition and thrombomodulin expression. J R Soc Interface 11:20131079
Jiang YZ, Jiménez JM, Ou K, McCormick ME, Zhang LD, Davies PF. 2014. Hemodynamic disturbed flow induces differential DNA methylation of endothelial kruppel-like factor 4 promoter in vitro and in vivo. Circ Res 115:32-43
Davies PF, Manduchi E, Stoeckert CJ, Jiménez JM, Jiang YZ. 2014. Emerging topic: flow-related epigenetic regulation of endothelial phenotype through DNA methylation. Vascul Pharmacol 62:88-93
Jiménez JM, Smits AJ. 2011. Tip and Junction Vortices Generated by the Sail of a Yawed Submarine Model at Low Reynolds Numbers. Journal of Fluids Engineering-Transactions of the Asme 133:-
Jiménez JM, Reynolds RT, Smits AJ. 2010. The Effects of Fins on the Intermediate Wake of a Submarine Model. Journal of Fluids Engineering-Transactions of the ASME 132
Jiménez JM, Hultmark M, Smits AJ. 2010. The intermediate wake of a body of revolution at high Reynolds numbers. J Fluid Mech 659:516-39
Jiménez JM, Davies PF. 2009. Hemodynamically driven stent strut design. Ann Biomed Eng 37:1483-94

Honors

2016 BMES Innovation and Career Development Award
2013 Poster Presentation Prize - 42nd Annual Philadelphia Workshop on Hemostasis, Thrombosis and Atherosclerosis
2011 - 2016 Mentored Quantitative Research Development Award - NIH
2007-2010 Ruth L. Kirschstein Institutional National Research Service Award – NIH

Bernd F. Schliemann

Senior Lecturer

Chief Undergraduate Advisor

Gunness Lab 7
University of Massachusetts, Amherst
160 Governors Drive
Amherst, MA 01003

bfschlie@umass.edu

(413) 545 - 6251

(413) 545 - 1027 (fax)

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Education

Ph.D., University of Massachusetts Amherst, 2012
M.B.A., University of Massachusetts Amherst, 2003
M.S.I.E., Georgia Institute of Technology, 1996
B.S., United States Military Academy at West Point, 1985

Research

Program Area:

Mechanical Engineering

Links

CV:

schliemann CV 1608.pdf

Maureen Lynch

Visiting Research Professor

LSL N575

LSL N575
University of Massachusetts
160 Governors Drive
Amherst, MA 01003-2210

maureenlynch@umass.edu

413-545-6689

413-545-1027

Lynch Research Group

Institute for Applied Life Sciences

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Education

B.S., Clemson University, Mechanical Engineering, 2005
M.S./Ph.D., Cornell University, Mechanical Engineering, 2010
Postdoctoral Fellow, Cornell University, Biomedical Engineering

Research

The current standard of care for bone metastasis is therapies targeting the cells that degrade bone. These cells are directed by cancer cells to degrade bone in order to release pro-tumorigenic growth factors stored within the skeletal extracellular matrix. These therapies are not curative and do not halt metastasis-mediated bone degradation, indicating additional factors contribute to bone degradation. My research program focuses on the skeletal mechanical environment and its regulation of cancer. Specifically, I will investigate 1) the skeleton’s mechanical environment and its regulation of the remodeling process, and 2) the role of osteoblastic cells, which comprise the principal sensor and effector cells of mechanical cues, in metastatic processes. My long-term goal is to identify novel therapeutic targets for treating and preventing bone metastases as well as cancer-associated reductions in bone strength. My experimental approach uses novel in vivo and in vitro mechanical loading model systems to correlate cellular function with cancer pathogenesis, tissue-level changes in tumor burden, and skeletal tissue strength.

Program Area:

Mechanical Engineering

Research Area:

Publications

Lynch ME and Fischbach C. “Biomechanical forces in the skeleton and their relevance to bone metastasis: biology and engineering considerations.” Advanced Drug Delivery Reviews, 79-80: 119-34, 2014. doi: 10.1016/j.addr.2014.08.009.
Main RP, Lynch ME, van der Meulen MCH. “Load-induced changes in bone stiffness and cancellous and cortical bone mass following tibial compression diminish with age in female mice.” The Journal of Experimental Biology, 217: 1775-83, 2014. doi: 10.1242/jeb.085522.
Lynch ME, Brooks DJ, Mohanan S, Lee MJ, Polamraju P, Dent KC, Bonassar L, van der Meulen MCH, Fischbach C. “In Vivo Tibial Compression Decreases Osteolysis and Tumor Formation in a Human Breast Cancer Metastasis Model.” Journal of Bone and Mineral Research, 28: 2357-2367, 2013. doi: 10.1002/jbmr.1966.
Infanger DW, Lynch ME, Fischbach C. “Engineered Culture Models for Studies of Tumor-Microenvironment Interactions.” Annual Review of Biomedical Engineering, 15: 29-53, 2013. doi: 10.1146/annurev-bioeng-071811-150028.
Lynch ME, Main RP, Xu Q, Schmicker TL, Schaffler MB, Wright TM, van der Meulen MCH. “Tibial Compression increases Cortical and Cancellous Bone Mass in Adult Female Mice.” Bone, 49: 439-46, 2010. doi: 10.1016/j.bone.2011.05.017.
Lynch ME, Main RP, Walsh DJ, Xu Q, Schaffler MB, Wright TM, van der Meulen MCH. “Cancellous bone adaptation to tibial compression is not sex-dependent in growing mice.” Journal of Applied Physiology, 109:685-691, 2010. doi: 10.1152/japplphysiol.00210.2010.
Main RP, Lynch ME, van der Meulen MCH. “In vivo tibial stiffness is maintained by whole bone morphology and cross-sectional geometry in growing female mice.” Journal of Biomechanics, 43:2689-2694, 2010. doi: 10.1016/j.jbiomech.2010.06.019.

Links

Lab Affiliation:

Lynch Research Group

Institute for Applied Life Sciences

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